Fluidigm Helios Mass Cytometer with Hyperion Tissue Imager

CyTOF 2 Upgraded To Helios Mass Cytometer, Helios Mass Cytometer, And Hyperion Tissue Imager

Helios™, a CyTOF® system, comprises the most recent advances in mass cytometry and is designed to provide a new and improved tool for bioanalytical single-cell detection and analysis. This high-performance mass cytometer, from the CyTOF family of instruments, enables the analysis of more than 40 markers and uniquely allows their quantitative determination with negligible spectral overlap, a result of exquisite resolution between mass detection channels. Helios provides users with 135 detection channels that can simultaneously resolve multiple elemental probes at high acquisition rates, thereby maximizing the per-cell information obtained from a single sample. The expanded mass range of 75–209 amu and superior mass resolution provide researchers with the ability to differentiate adjacent peaks. The Helios system provides fast instrument startup, an easy-to-use pneumatic sample loading system, an improved cell detection rate, and enhanced data storage capabilities. These attributes provide researchers with an unparalleled ability to generate high-resolution phenotypic and functional profiles of cells from normal and diseased states.

The Hyperion™ Imaging System is the world’s first and only commercially available metal-tagged, antibody-directed Imaging Mass Cytometry™ (IMC™) platform that allows highly multiplexed imaging with 135 available channels. The system is designed to detect metal-tagged antibodies bound to proteins in biological samples using standard staining methods. The platform can simultaneously detect 4 to 37 protein markers in biological samples including fixed tissue sections or cells deposited onto glass slides (liquid biopsies). This allows researchers to investigate cellular subpopulations in various tissue microenvironments. The system allows for cellular profiling in spatial proximity, enabling subpopulation profiling and exploration of relationships of neighboring cells within the context of the tissue structure.